N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis
نویسندگان
چکیده
Base-promoted 5-exo-dig cyclizations of aza-propargylglycinamides provided N-amino-imidazolin-2-one peptide mimics, which exhibited turn geometry in X-ray crystallographic and NMR spectroscopic analyses. Sonogashira coupling prior to cyclization afforded N-amino-imidazolin-2-ones with diverse 4-position aromatic substituents with potential to serve as Phe and Trp mimics.
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عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2012